Our Senior Research Scientist Dr Michael Schwertner introduced our new Cryo-Correlative Microscopy Stage, the CMS196V4, to researchers at the Centre for Ultrastructural Imaging (CUI) at Kings College London as part of the ‘‘Imaging Bites" seminar series. The CMS196V4 enables fluorescence sample mapping for correlative methods with cryo-electron microscopy (cryo-EM). In his presentation, Michael explored the skills and tools unique to cryo-samples and discussed applications within the Centre for Ultrastructural Imaging, highlighting how cryo-correlative methods can enhance the study of biological samples. The seminar also explored how vitrified cryo-samples offer superior structural preservation of biological samples and are compatible with the vacuum conditions of the electron microscope as well as light microscopy methods, notably fluorescence.

At the end of the presentation there was an opportunity to view the CMS196V4 with accessories, including a short Q&A on how workflows directly connect with existing JEOL instrumentation at CUI, such as the CRYOARM TEM and the FIB SEM.