polymers

Deciphering the role of amphiphilic polymer combinations in the formation of ternary griseofulvin amorphous solid dispersions using Linkam's THMS600

Researchers at Aristotle University of Thessaloniki, NatPro-AUTH, CIRI-AUTH, in Greece used Linkam’s THMS600 to investigate how different combinations of amphiphilic polymers influence the formation, physical stability, and dissolution performance of ternary amorphous solid dispersions (ASDs) of griseofulvin (GRF), a poorly soluble drug with a strong tendency to recrystallise.

Studying Phase Transitions in Pharmaceuticals using Linkam’s DSC450 in combination with TASC.

Polymorphism in pharmaceutical solids has great implications on both the processing and the performance of solid pharmaceutical products. This app note details work from the School of Pharmacy at UCL using TASC with our DSC450 to characterise polymorphic transitions in the pharmaceutical active compound flufenamic acid .