Pharmaceutical Applications

Linkam has been developing sample characterisation solutions to help push the boundaries of science for over 40 years. Understanding the thermal properties of materials is essential in many areas of the pharmaceutical industry.

Linkam has worked closely with the pharmaceutical industry to develop solutions for some of the key problems from drug development and formulation to manufacturing, quality assurance, packaging and storage. The development of our optical DSC, humidity control and lyophilisation systems have enhanced the ability to control the temperature of your sample to enable more detailed characterisation of materials.

We have solutions for lyophilisation, thermoanalysis, dissolution studies, shelf-life testing and many more.

Linkam systems are compatible with light microscopy and spectroscopy techniques including Raman, FT-IR and X-ray.

Related Products

Published Papers

Research Papers List
HFS600 on IS closed down.jpg
research paper, open source
pharma, Imaging Station
Investigating the Effects of Solid Particle Containing Inks on the Printing Quality of Porous Pharmaceutical Structures Fabricated by 3D Semi-Solid Extrusion Printing using Linkam’s Imaging Station
research paper, open source
pharma, Imaging Station

3D printed pharmaceutical products open the door to an exciting world of individually tailored drugs, unique for each patient. In this paper the drying process of single and multi-layered printed materials was monitored using the Linkam Imaging Station, monitoring changes in pore size as the 3D printed paracetamol was dried.

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research paper, open source
pharma, Imaging Station
LTS420 open.jpg
research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea
A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens
research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea

Researchers at the University of Liverpool, UK used a Linkam TST350 stage (now replaced by the LTS420) for this study.

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research paper
materials, tensile stage, drug delivery, hydrogel, pharma, antimicrobial, cornea
DSC 450 closed.jpg
research paper, open source
pharma, DSC
Hot stage microscopy and its applications in pharmaceutical characterisation
research paper, open source
pharma, DSC

Find out how hot stage microscopy (HSM) and Differential Scanning Calorimetry (DSC) can be used for pharmaceutical applications.

Choose Linkam’s THMS600, for hot stage microscopy, or our DSC450 for optical differential scanning microscopy.

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research paper, open source
pharma, DSC

Application Notes

Application Notes
THMS600 floaty lid.jpg
Scientific paper
THMS600, pharma, polymers
Deciphering the role of amphiphilic polymer combinations in the formation of ternary griseofulvin amorphous solid dispersions using Linkam's THMS600
Scientific paper
THMS600, pharma, polymers

Researchers at Aristotle University of Thessaloniki, NatPro-AUTH, CIRI-AUTH, in Greece used Linkam’s THMS600 to investigate how different combinations of amphiphilic polymers influence the formation, physical stability, and dissolution performance of ternary amorphous solid dispersions (ASDs) of griseofulvin (GRF), a poorly soluble drug with a strong tendency to recrystallise.

Scientific paper
THMS600, pharma, polymers
FTIR600 open.jpg
Application Note
imaging, ftir600, pharma
Studying a New Polymorph of Metacetamol using Linkam’s FTIR600
Application Note
imaging, ftir600, pharma

The FTIR600 stage is used to measure IR spectra at variable temperatures, and transformations between polymorphs followed in situ by heating and cooling the samples in the chamber.

Application Note
imaging, ftir600, pharma
DSC 450 open.jpg
Application Note
DSC, pharma
Investigating drug-polymer interactions using optical DSC
Application Note
DSC, pharma

Researchers from the University of Hertfordshire’s School of Life and Medical Sciences collaborated with Linkam to provide an in-depth analysis into how the optical DSC450 and TASC can be used to characterise drug-polymer-excipient systems for pharmaceutical applications. Read the full case study here.

Application Note
DSC, pharma
Annotation 2020-05-29 143033.png
Application Note
DSC, TASC, pharma
A Novel Thermal Microscopic Imaging Tool for Rapid Pre-Formulation Screening of Solid Dispersions
Application Note
DSC, TASC, pharma

See how TASC can be used as a rapid and inexpensive screening method during the preformulation stage of solid dispersion based pharmaceutical products.

Application Note
DSC, TASC, pharma
DSC 450 open.jpg
Application Note
DSC, TASC, polymers, imaging, pharma
Studying Phase Transitions in Pharmaceuticals using Linkam’s DSC450 in combination with TASC.
Application Note
DSC, TASC, polymers, imaging, pharma

Polymorphism in pharmaceutical solids has great implications on both the processing and the performance of solid pharmaceutical products. This app note details work from the School of Pharmacy at UCL using TASC with our DSC450 to characterise polymorphic transitions in the pharmaceutical active compound flufenamic acid .

Application Note
DSC, TASC, polymers, imaging, pharma

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