research paper

Elastic response of (1−x)Ba(Ti0.8Zr0.2)O3 – x(Ba0.7Ca0.3)TiO3 (x=0.45–0.55) and the role of the intermediate orthorhombic phase in enhancing the piezoelectric coupling using Linkam’s HFS600E-PB4

Using Linkam’s HFS600E-PB4 Linkam probe stage at temperatures down to -70 °C (200K), this study looks at how temperature-dependent phase transitions affect the properties of piezoelectric materials, finding that ideal properties peaked around the low-temperature phase transitions.

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Optothermotronic effect as an ultrasensitive thermal sensing technology for solid-state electronics using Linkam’s HFS600E-PB4.

Researchers study the effect of thermal excitation on semiconducting sensor materials using a Linkam probe stage, the HFS600E-PB4. They explore the temperature sensing performance of these semiconductor nanofilms.

An Experimental Study of the Formation of Talc through CaMg(CO3)2–SiO2–H2O Interaction at 100–200∘C and Vapor-Saturation Pressures using Linkam’s CAP500

Researchers use the Linkam CAP500 with fused silica capillaries to study the formation of talc, observing the process using techniques such as Raman spectroscopy and X-ray diffraction.

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Full Open Access article available via CC BY 3.0.

Wan, Ye, et al. "An Experimental Study of the Formation of Talc through CaMg (CO3) 2–SiO2–H2O Interaction at 100–200 C and Vapor-Saturation Pressures." Geofluids 2017 (2017).

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X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser

Researchers use the Linkam CMS196 for imaging cryopreserved human prostate cancer cells with X-ray tomography. The CMS196 was used for cryo-fluorescence imaging of human PC3 prostate cancer cells, bringing insight into a new material used for a promising new non-invasive theraputive cancer treatment technique, Photo-Dynamic Therapy (PDT).

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Full article available per CC BY 4.0.

Bolitho, E.M., Sanchez-Cano, C., Huang, H. et al. X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser. J Biol Inorg Chem 25, 295–303 (2020). https://doi.org/10.1007/s00775-020-01761-8

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Imaging endosomes and autophagosomes in whole mammalian cells using correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo-CLXM)

Researchers use the Linkam CMS196 with correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo-CLXM) to observe endosomes and autophagosomes in mammalian cells.

Scientists at the London Research Institute of Cancer Research UK use the Linkam CMS196 for imaging mammalian cells with cryo-CLXM microscopy.

Ultramicroscopy 143 (2014) 77–87

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Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo FIB /SEM Tomography

Researchers use the Linkam CMS196 as part of a Confocal Cryo Fluorescence Microscopy setup to image vitrified biological samples.

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Schertel, Andreas, et al. "Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo FIB/SEM Tomography." European Microscopy Congress 2016: Proceedings. Weinheim, Germany: Wiley‐VCH Verlag GmbH & Co. KGaA, 2016.

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Key composition optimisation of meat processed protein source by vacuum freeze-drying technology using Linkam’s FDCS196

This study, using Linkam’s FDCS196 Freeze Drying System, shows how the freeze-drying process can be used to preserve meat and discusses the effect of system pressure on the freeze drying efficiency.

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Prickett, Richelle C., et al. "Effect of supercooling and cell volume on intracellular ice formation." Cryobiology 70.2 (2015): 156-163.

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Effect of supercooling and cell volume on intracellular ice formation using Linkam’s FDCS196

Studying the effect of supercooling and cell volume on intracellular ice formation (IIF), using Linkam’s Freeze Drying system the FDCS196.

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Prickett, Richelle C., et al. "Effect of supercooling and cell volume on intracellular ice formation." Cryobiology 70.2 (2015): 156-163.

Using Linkam’s FDCS196 to Investigate How Small Molecule Ice Recrystallisation Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations

Researchers at the University of Ottowa, Canada used Linkam’s Freeze Drying system FDCS196 to cryopreserve red blood cells with slow cooling rates prior to storage at -80°C.

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Capicciotti, C.J. et al. Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations. Sci. Rep. 5, 9692; DOI:10.1038/srep09692 (2015).

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Operando micro-spectroscopy on ZSM-5 containing extrudates during the oligomerization of 1-hexene

This article studies the impact of the binder material in industrial catalysts. Using the Linkam TS1500V to perform catalytic reactions at 250 and 300°C, the authors used operando spectrocopy and in situ confocal fluoroscence microscopy to show how different binder materials affect the final material composition.